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Diamine Put [NH 2 (CH 2 ) 4 NH 2 ], triamine Spd [NH 2 (CH 2 ) 3 NH(CH 2 ) 4 NH 2 ], tetramine Spm [NH 2 (CH 2 ) 3 NH(CH 2 ) 4 NH(CH 2 ) 3 NH 2 ] are most common PAs in higher plants which exist as soluble conjugated, and insoluble bound forms and differential forms of PAs function differently (Lefevre et al., 2001)

By month 4, GI side effects fade into background noise for 85%+ of patients, leaving appetite suppression as the primary ongoing effect, which is the desired therapeutic response